Post-Doc H/F Sanofi

Détail du poste

Post-Doc Position in Sanofi / WIDGET consortium

Expert in Biology, Molecular Biology, NGS & Single Cells

Abstract :

As part of the WIDGeT consortium1 (23M€, 5 years), we are currently researching a Postdoctoral candidate with a strong background in molecular biology and NGS for single cell application.

Overview of the research project :

The WIDGeT consortium (Viral Vector Intelligent Design for Gene Therapy) aims to accelerate the development of gene therapies using viral vectors derived from adeno-associated viruses (AAV) for the treatment of age-related macular degeneration and hereditary podocytopathies (kidney diseases), leveraging the potential of artificial intelligence (AI). As part of this challenging consortium, our team proposed to develop a new technology to provide very sensitive information of AAV's transgene expression at the single cell level. This technology is based on droplet microfluidic, DNA barcoded, scRT-PCR and NGS.

Responsibilities :

·Develop, design, and execute complex experiments and analyze data.

·Write (Lab Book) and Present (PowerPoint) research findings.

·Mentor and co-supervise engineer, technician and undergraduate students involved in the research project.

·Report and collaborate with other members of the consortium.

Qualifications :

·Ph.D. in biology or molecular biology

·Strong Experience in Single-cell RNA sequencing

·Strong background in molecular biology, NGS experiments and analysis.

·Background in single cells experiment (10x, flow cytometer...)

·Appetite for bench work & wet lab

·Appetite for challenging project

·Background in Bioinformatic

·Familiarity with statistical software (Prism, Spotfire, other...)

·Fluent in English

·Excellent written and verbal communication skills.

·Experience with Recombinant AAV is a plus.

·Knowledge in organoids/tissues preparation is a plus.

·Experience in screening is a plus.

·Background in Droplet microfluidic is optional.

The Project Team :

A dedicated team was created in 2024 to tackle this challenging project. The team is composed of one researcher, one engineer and one technician.

The Lab :

Our innovative Team (~8 people) is based in Vitry-Sur-Seine (Suburbs of Paris) at Sanofi R&D site. We have two laboratories (L1 & L2) dedicated to droplet microfluidic technology, with access to diverse technologies (ARIA Fusion (FACS), PCR, qPCR and NextSeq Illumina).

Duration & Salary :

18 months to 4 years

Language :

English / French (optional)

References :

1

La diversité et l'inclusion sont les piliers de la manière dont Sanofi fonctionne et font partie intégrante des valeurs de la société. Nous respectons la diversité de nos collaborateurs, tout comme celle de leurs parcours et expériences. Afin de bénéficier de la richesse qu'apporte la diversité, Sanofi s'engage à donner l'exemple en matière d'inclusion et à favoriser un environnement de travail où les différences peuvent prospérer et contribuer à aider les patients à retrouver une vie meilleure.

Dans le cadre de son engagement diversité, Sanofi accueille et intègre des collaborateurs en situation de handicap.